A significant association was also observed for rs1265181 present at –1691 bp from the transcription initiation site of PSORS1C3, a lncRNA discovered in a linkage analysis on psoriasis and immune-mediated diseases [36], regulating the expression of the nearby POU5F1 gene, which encodes OCT4, the main regulator of pluripotency in stem cells [37]. The gene discussed is POU5F1; the disease is psoriasis.