The reason HLA-Cw6 allele associates with response to biologics blocking IFN-γ and IL-17 cytokines could depend on its capability to influence the presentation of epitopes of different autoantigens, such as the cathelecidin LL37, which is efficiently recognized by circulating CD8+ T cells with a psoriasis-like cytokine profile (IFN-γhigh and IL-17high) [15]. This evidence concerns the gene CD8A and psoriasis.