HLA-C risk alleles have been implicated in psoriasis development and progression, since they preferentially present (auto)antigens, such as the LL37 cathelecidin and the disintegrin and metalloprotease domain containing thrombospondin type 1 motif-like 5 (ADAMTSL5) protein, to CD8+ T cells with a cytokine and skin-homing receptor profile typical of psoriatic skin (IL-17high, IFN-γhigh, CLA+, CCR6+ and CCR10+) [15,16]. Here, HLA-C is linked to psoriasis.