EGFR, prostate stem cell antigen (PSCA), mesothelin (MSLN), carcinoembryonic antigen (CEA), mucin 1 (MUC1), PD-L1, inactive tyrosine-protein kinase transmembrane receptor (ROR1), CD80/CD86, HER2 are the antigens most frequently targeted in NSCLC. The gene discussed is CD274; the disease is non-small cell lung carcinoma.