ITGAM and Hepatic fibrosis: A seminal work using CD11b-DTR mice showed that depletion of CD11b+ cells (iMΦs) during the induction phase of CCl4-induced liver fibrosis attenuated the disease severity, whereas cell depletion at the recovery phase delayed tissue repair (36), suggesting that liver iMΦs could play distinctive roles at different stages of the disease process.