ANKS6 and cyst: Interestingly, levels of both COX2 and PGE2 are increased in PKD models and patient cyst fluid, and inhibition of COX2 has been shown to ameliorate PKD in Anks6+/– (Han:SPRD Cy/+) rats, a nonorthologous ADPKD model, and in Pkd2WS25/− mice.