Increasing severity of kidney damage, assessed by markers of tubular injury such as increased urinary neutrophil gelatinase-associated lipocalin (NGAL) [13], and increased urinary kidney injury molecule-1 (KIM-1) [14], are associated with a greater risk of chronic kidney disease (CKD) and end stage renal disease [15,16]. Here, HAVCR1 is linked to chronic kidney disease.