The major tau kinases involved in AD are glycogen synthase kinase-3α/β (GSK-3α/β), GSK-3α/β (pS21/pS9), cyclin-dependent kinase 5 (CDK5) and its activator P35, extracellular signal-regulated kinase (ERK), ERKl/2(pT202/pY204), c-Jun N-terminal kinase (JNK), JNK (pT183/pY185), calcium/calmodulin-dependent protein kinase II (CaMKII), and CaMKII (pT286). The gene discussed is CDK5; the disease is Alzheimer disease.