Of the genes found to be significantly differentially expressed in the clinical cohort, A3GALT2, CASP1, CASP4, CASP5, CASP8, CASP9, CCR5, CD4, FPR2, PLAC8, and TMEM88 were significantly greater in neuropathic pain patients than controls, whereas expression of SH3BGRL3 was significantly less in neuropathic pain patients versus controls. This evidence concerns the gene CASP8 and neuropathic pain.