A series of causative genes including SLC5A1 (SGLT1) for glucose-galactose malabsorption (Martín et al. 1996), and SLC26A3 (DRA) for congenital chloride diarrhea (Höglund et al. 1996) were the first to be identified, followed later by MYO5B for microvillus inclusion disease (Müller et al. 2008) and EPCAM for congenital tufting enteropathy (Sivagnanam et al. 2008). The gene discussed is EPCAM; the disease is Intestinal epithelial dysplasia.