Recently, congenital glucagon-like peptide-1 (GLP-1) deficiency was identified in several Mitchell-Riley syndrome patients, suggesting a potential pathogenic explanation for the diarrhea; synthetic GLP-1 analog liraglutide was administered, resulting in diarrhea improvement in all patients, with no effect on glycemic status (Nóbrega et al. 2021). This evidence concerns the gene GCG and hyperinsulinemic hypoglycemia, familial, 4.