However, in the group with permanent dentition, the A allele of the SNP in KLK4 (rs2235091) was statistically significantly more common in children with dental caries (p = 0.014, OR = 1.37, 95% CI 1.05–1.80) and it was also associated with dental caries in the additive (p = 0.047) and dominant (p = 0.034) models. This evidence concerns the gene KLK4 and dental caries.