Co-occurrence of the homozygous minor alleles (OR = 18.58; 95% CI: 6.54–52.79; p < 0.00001) or genotypes (OR = 18.58; 95% CI: 4.24–81.36; p < 0.00001) in the two associated SNPs of IL1B (rs16944 and rs1143627) were associated with increased risk of keratitis. Here, IL1B is linked to keratitis.