Concerning the type of Ig deficiency, 2 out of 16 patients (12.5%) with IgG, IgA, and IgM deficiency were R, while 5 out of 6 (83.3%) with IgG deficiency only were R. In the same line, 7 out of 16 (43.8%) with IgG, IgA, and IgM deficiency were NR, while none of the 6 patients with IgG deficiency only were NR (p = 0.02). This evidence concerns the gene CD79A and Decreased circulating total IgM.