The majority of host-virus homologous proteins are involved in some of the most important autoimmune disease pathways, such as TNF-related weak inducer of apoptosis (TWEAK) signaling, cellular components involved in local acute inflammatory responses, IL-11 and IL6 signaling pathways, generic transcription pathways, p53 signaling, ataxia-telangiectasia mutated (ATM) signaling, and inflammation mediated by chemokine and cytokine signaling pathways. The gene discussed is ATM; the disease is autoimmune disease.