For instance, some stx2 subtypes—such as stx2a, stx2c, and stx2d—are frequently linked to a higher risk of developing HUS, whereas others—such as stx2e, stx2b, stx2f, and stx2g—have been linked to milder diseases [63,64,65]. The gene discussed is STX2; the disease is hemolytic-uremic syndrome.