Thus, the present study aimed at implementing the routine use of the StandardTM G6PD quantitative test at malaria treatment units (MTUs) in two municipalities in the countryside of the Brazilian Amazon, assessing the reliability of interpretation by health care professionals (HCPs), the test performance in the field, the clinical impact of test implementation to prevent/avoid AHA cases after malaria diagnosis, and the perceptions of HCPs and patients about the test implementation. Here, G6PD is linked to malaria.