JAK2 and chronic myelogenous leukemia, BCR-ABL1 positive: Several examples are given, including that curcumol isolated from Curcuma longa L. can induce the differentiation and apoptosis of CML cells by blocking the BCR/ABL-JAK2/STAT3 and PI3K/AKT-JNK signaling pathways and activating the BH3-only gene [11].