Combining the network pharmacology analysis, GO, KEGG and Reactome enrichment analysis, PD-L1 expression and the PD-1 checkpoint pathway in cancer, JAK/STAT, TGF-β, estrogen, Notch and Wnt were the main signaling pathways regulated by GD-NAIs for the treatment of CML. The gene discussed is CD274; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.