Moreover, we also hypothesized the potential mechanisms of gastrodin on actin filament polymerization, renin–angiotensin system (RAS) and anti-ferroptosis in bone metabolism, and proposed that the combinations of gastrodin with Mg2+, angiotensin type 2 receptor blockers or artemisinin may have greater potential to anti-osteoporosis. The gene discussed is REN; the disease is osteoporosis.