CD8A and neoplasm: Additionally, with multiplexed immunofluorescence to investigate immunophenotype, patients who exhibited a derived neutrophil-to-lymphocyte ratio (dNLR) of <2.6 had significantly greater infiltration of tumor-associated CD8+, FOXP3+, PD-1+ immune cells, and PD-1+ CD8+ T cells in tumor tissue than those with a dNLR ≥ 2.6 [20].