CTLA4 and neoplasm: Our later analysis also finds that, firstly, the degree of tumor-promoting immune cell infiltration in the high-risk group is significantly higher than that in the low-risk group; secondly, the TIDE algorithm shows the dysfunction and exhaustion of T cells in the high-risk group; and finally, some suppressors in the TME, such as PD-1, CTLA4, TIGIT, TRIM3, LAG3, CAFs marker genes are also significantly higher in the high-risk group.