TNFSF10 and B-cell non-Hodgkin lymphoma: Using the adeno-associated virus- or lentivirus-mediated overexpression method to genetically modify B-cell non-Hodgkin lymphoma (B-NHL) cells to produce secretable TRAIL (sTRAIL), Yuan et al. found that TRAIL gene expression driven by CD20 promoter could inhibit the proliferation of B-NHL cells in vivo and in vitro [21].