We found that rhTRAIL downregulated the expression levels of TRAIL receptors TNFRSF10A and TNFRSF10B of B-ALL cells in vitro, whereas MSC secreted-sTRAIL did not reduce, but upregulated the expression levels of TNFRSF10A and TNFRSF10B. This evidence concerns the gene TNFRSF10A and acute lymphoblastic leukemia.