Overall, plasma aspartate transaminase (AST), alanine transaminase (ALT) and creatine kinase (CK) concentrations for individual HoFH patients remained stable with treatment with evinacumab, the corresponding liver and enzyme concentrations not exceeding three times the upper limit of normal (ULN) (Figure 6). This evidence concerns the gene GPT and homozygous familial hypercholesterolemia.