POMC and Cushing syndrome due to macronodular adrenal hyperplasia: Cushing’s disease (CD), the most common cause of adrenocorticotropic hormone (ACTH)-dependent Cushing’s syndrome (CS), generally results from ACTH-secreting pituitary tumors, but in rare cases, it may also be caused by ectopic (nonpituitary) ACTH-secreting tumors [1].