A structural analogue of 5, cyclo-(Pro-Tyr), is toxic and selective against MCF-7 cells isolated from Barrientosiimonas humi [40], and has potential anticancer effects on N-diethyl-nitrosamine-induced hepatocellular carcinoma in mice via the PI3K/AKT signaling pathway [41]. The gene discussed is AKT1; the disease is hepatocellular carcinoma.