On the other hand, a common natural polyphenol, curcumin, is also known for its cytotoxicity against GBM and modulates some common pathways that are misregulated mostly during the GBM progression, including NF-κB, JAK/STAT, P13K/AK, p53, SHH (Sonic Hedgehog Signaling Molecule), and Rb pathways, reviews in [187,188,189]. The gene discussed is SHH; the disease is glioblastoma.