HSP90AA1 and glioblastoma: Specifically, Boridy et al. found that celastrol induced apoptosis in GBM cells by regulating the proteostasis network, such as inducing expression of Hsp90 and Hsp72, and autophagy substrate, P62 (sequestosome 1), suggesting that by inducing proteotoxic stress, celastrol promotes cell death [234].