In the okadaic acid (OA)-induced AD rat model, HMPB-AAG nano-agents ameliorated memory impairments and tau-related pathologies by boosting Hsp40/Hsp70-mediated p-tau degradation, reducing oxidative stress, mitigating neurotoxicity, and preventing neuronal death and synaptic loss [139]. This evidence concerns the gene MAPT and Alzheimer disease.