Gedunin reduces cell proliferation and induces apoptosis in GBM cell lines by attenuating key survival signaling pathways like Akt/mTOR, NF-kB, and apoptotic markers such as PARP (poly(ADP-ribose) polymerase), caspases, and Bcl-xL [219]. This evidence concerns the gene AKT1 and glioblastoma.