CDK4 and glioblastoma: A mechanistic study by Ho et al. showed that N-vinylpyrrolidone-AUY922, an Hsp90 inhibitor, can promote cell death of patient-derived GBM cells by downregulating NF1 (Neurofibromin), PDGFRA, EGFR, and CDK4 expression while inducing apoptosis and autophagy [78].