TNF and obesity due to melanocortin 4 receptor deficiency: The obesity adipocyte inflammation observed on administering luteolin reduces inflammation by reducing the proinflammatory mediators in macrophages such as tumor necrosis factor-α (TNFα), monocyte chemoattractant protein (MCP-1), and NO, while co-cultivating with 3T3-L1 adipocytes and RAW264 macrophages.