In summary, the morphology and related proteins of white fat in mice showed browning characteristics with DNA methyltransferase inhibitor 5-Aza-dC, which affected miR-133a expression through epigenetic regulation and acted on the browning marker protein Prdm16, resulting in adipocyte browning, which in turn may act as a resistance to obesity. The gene discussed is PRDM16; the disease is Obesity.