INS and type 2 diabetes mellitus: The Dallas Heart Study was the first large study (n = 1557) to reveal a positive correlation between shorter-chain saturated fatty acid ceramides (Cer18:0, Cer16:0, Cer20:0) with unfavorable adiposity, and lipid and insulin resistance; nevertheless, plasma ceramides were not independently associated with T2DM after adjustment for clinical factors [9].