NFE2L2 and COVID-19: With this explanation, Gumus et al. justifies the lower values of Nrf2 in symptomatic compared to asymptomatic COVID-19 pediatric patients [34], and Olagnier et al. uses this mechanism to describe a decrease in the Nrf2 expression in the lung biopsies of patients suffering from ARDS caused by the SARS-CoV2 virus.