EGFR and non-small cell lung carcinoma: Thus, the present study performed a systematic review and a meta-analysis of the available clinical data from representative head-to-head EGFR TKIs comparison RCTs to evaluate the efficacy of the EGFR TKIs on the progression-free survival (PFS) and overall survival (OS) of older adult patients with advanced EGFR-mutated NSCLC.