KCNH2 and cancer: For instance, coexpression of hERG and tumour necrosis factor receptor 1 (TNFR1) has been found at the cell membrane of both SKBR3 and SH-SY5Y cell lines, suggesting a hERG role in recruiting TNFR1 to the membrane, therefore enhancing TNF-α-induced cancer cell proliferation [39].