According to the published studies, we have observed that cirrhosis impaired the ability of HDL-C to inhibit lipopolysaccharide-induced (LPS) activation of the pro-inflammatory transcription factor NF-kB and subsequent production of interleukin-6 (IL-6), interleukin-8 (IL-8, and tumor necrosis factor-α (TNF-α) in monocytes [18]. Here, TNF is linked to Cirrhosis.