The CYP2D6*10 SNP is relevant to tramadol pharmacokinetics and opioid dose requirement, while SNPs within UGT2B7 (rs7439366), ABAT (rs1641025), and P2RX7 (rs1718125) have demonstrated some level of potential clinical relevance to cancer pain pharmacogenomics in Asian patients. The gene discussed is P2RX7; the disease is cancer.