BMP2 and 22q11.2 deletion syndrome: However, it was interesting that miR-93 was dysregulated in both 22q11DS and AIS specimens, given that this miRNA is involved in osteogenic differentiation by targeting the bone morphogenetic protein-2, in osteoblast mineralization and in the bone mineral density, which are well-established pathways in the etiology of scoliosis [60,61,62,63,64,65,66].