IGFBP3 and cancer: On the other hand, none of the dHCPPIs was the same for all cancer types studied, and five interactions were the same in at most seven different cancers (i.e., CAV1-CTNNB1, COL1A1-IGFBP3, LDHA-LDHB, PCNA-GAPDH, and PSMB7-PSMB3).