Of the 29 participants from both sites, P/LP variants associated with the following conditions were returned: increased risk for arrhythmia, aortopathy, breast cancer, cardiomyopathy/heart failure, malignant hyperthermia, hypercholesterolemia, tuberous sclerosis complex, chronic kidney disease, Fabry disease (female), and CACNA1A associated neuropathologies (Table 1). Here, CACNA1A is linked to heart failure.