EGFR (Arg255Gln), EGFR (Ala647Thr), EGFR (Leu858Arg), KRAS (Gly12Cys), ALK (Pro254Thr), ALK (Trp288Ser), ALK (Glu797Lys), ROS (Glu1902Lys), PIK3CA (Met1043Ile), ROS (Leu567Val), and ROS (Phe1153Leu) mutations were present only in patients with adenocarcinoma. This evidence concerns the gene EGFR and adenocarcinoma.