PTX3 and Ito hypomelanosis: There have been two seminal reports describing the use of Ptx3 as a biomarker in the analysis of BALF samples from critically ill patients: Li et al. reported a study involving 35 proven and 16 suspected IPA groups [10], while Kabbani et al. reported fast Ptx3 secretion kinetics in a study involving 15 patients with probable IPA, 30 with lower respiratory tract colonization, and 17 with positive GM and negative BALF culture results [9].