PTX3 and Ito hypomelanosis: The BALF Ptx3 threshold for the combined detection of IPA or IPM was 1653 pg/mL, with a sensitivity and specificity of 96.2% (95% CI = 80–100%) and 87.3% (95% CI = 77–94%), respectively, according to the ROC curve analysis (AUC = 0.9795, see source calculation in Supplementary Data S1.2).