Although there was no heterogeneity in the effect of tirofiban on favorable outcomes with respect to age, sex, ASPECTS, OTP time, use of t-PA and stroke etiology (p for interaction >0.05), tirofiban was associated with outcomes in the subgroup of time from onset to puncture ≤360 (aOR 1.91, 95% CI 1.20~4.41) and stroke due to LAA (aOR 1.91, 95% CI 1.88~4.15). Here, PLAT is linked to Stroke.