While most of Lynch syndrome studies in the literature are population-based studies, our approach is more clinically oriented focusing on patients affected with colorectal cancer or unaffected individuals with family history indicative for Lynch syndrome The aim of our study is to explore the prevalence of Lynch syndrome, frequency of MMR genes pathogenic variants and the genotype-phenotype correlation of Lynch syndrome in colorectal cancer in a selected high risk cohort of ethnically diverse individuals in Qatar. This evidence concerns the gene MRC1 and colorectal cancer.