MSH2 and cancer: Additionally, the difference in the distribution of the genes between affected and unaffected individuals was statistically significant (p < 0.005) after Bonferroni correction, and the fact that MLH1 and MSH2 genes were not reported in unaffected individuals could be attributed to the high penetrance of these 2 genes and their association with higher cancer risk compared to the remaining MMR and EPCAM genes which makes them less likely to be detected in unaffected individuals [32].