UPF1 and central nervous system cancer: Several studies have indicated that UPF1 is downregulated and related to poor prognosis in pancreatic adenosquamous carcinoma (PASC) [6], hepatocellular carcinoma (HCC) [7], gastric cancer (GC) [8], inflammatory myofibroblastic tumors (IMT) [9], thyroid cancer (TC) [10], ovarian cancer (OC) [11] and glioma [12].