ADAMTS2 and Ehlers-Danlos syndrome: This report has expanded the genotypic and phenotypic spectrum of the dermatosparaxis subtype of canine EDS by identifying two novel ADAMTS2 variants that, in the homozygous state, were the likely causes for the dermatosparactic form of canine EDS and by documenting the associated clinical histories and laboratory findings for seven dogs with EDS likely caused by these variants.