TARP and hydronephrosis: Over time, as more TARP-affected patients were identified by genetic testing, the cardinal clinical hallmarks of the original TARP extended to additional clinical manifestations, including congenital renal, vertebral, and cerebral/cerebellar anomalies, pulmonary hypoplasia, anorectal malformations, aplasia of fingers and toes, and hydronephrosis and hemodynamically significant hypertrophic obstructive cardiomyopathy [4,5].