miR-9-5p enhances the tumorigenic ability of hepatocellular carcinoma cells by targeting CPEB3 and ESR1 [54,55], but miR-9 plays a tumor suppressor role in hepatocellular carcinoma by regulating IGF2BP1, Sox11, and P21 [56,57,58,59]. This evidence concerns the gene ESR1 and hepatocellular carcinoma.