It has been known for several decades that the major histocompatibility complex (MHC), also known as human leukocyte antigen (HLA) in humans, located on the short arm of chromosome 6 and encoding for cell-surface proteins and molecules responsible for the regulation of the immune system, harbors the strongest contributor to MS risk, the HLA-DRB1*15:01 allele [1], and the most known protective locus for MS, the HLA-A*02:01 allele [2]. Here, HLA-DRB1 is linked to myeloid sarcoma.