Indeed, a study by Isobe et al. [13] investigating in a cohort of 586 MS patients the cumulative impact of HLA risk loci on clinical and MRI outcomes revealed a sex-specific association of HLAGB with subcortical GM fraction in women, mostly driven by the HLA-DRB1*15:01 haplotype. The gene discussed is HLA-DRB1; the disease is myeloid sarcoma.