We propose that these enriched HAR and PS genes (EIF4E, EIF5, EIF3M, DDX17, SRSF11, PSPC1, SUMO1, CAPZA1, PSMD14, and MNAT1) and the highly connected hub genes HNRNPA1, RBMX, PRKDC, and RANBP2 are key genes for both diagnostic biomarkers in preeclampsia and therapeutic intervention targets. This evidence concerns the gene CAPZA1 and preeclampsia.