Moreover, risk-associated alleles have been previously demonstrated to predict schizophrenia-relevant phenotypes such as lower IQ scores, lower cognitive processing speed, decreased hippocampus gray matter volume, and altered memory-linked fMRI signal [27,58,59].Since these markers are in moderate to strong linkage disequilibrium, the region of interest maps to a ∼3 kb segment of intron 2 of KCNH2 as a potential susceptibility locus. This evidence concerns the gene KCNH2 and schizophrenia.