TP63 and split hand-foot malformation: Moreover, there are complex ED syndromes, such as ankyloblepharon-ectodermal dysplasia-cleft lip/palate (AEC) syndrome (MIM #106260) and ectrodactyly-ectodermal dysplasia-cleft lip/palate (EEC) syndrome (MIM #604292), two dominantly inherited disorders caused by pathogenic variants of the gene TP63 (MIM *603273) that encodes a key transcription factor, tumor protein 63 (p63).