VEGFA and hepatocellular carcinoma: Animal experiments with H22 hepatoma cells demonstrated reduction of transplanted tumor grow caused by reducing DNA fragmentation and microvascular density and worsening the expression of signaling proteins, such as vascular endothelial growth factors (VEGF) and hypoxia-inducible factor 1α (HIF-1α), indicating an antiangiogenic and proapoptotic effect on H22 cells [62].