Thus, the selective TRPC6 inhibitor BI 749327 [89], and the pan-TRPC inhibitor 4-methyl-4-[3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl]-1,2,3-thiadiazole-5-carbox anilide (BTP2) [64] have been observed to reduce renal fibrosis induced by UUO [64,89] well as cardiac fibrosis and hypertrophy in mice subjected to chronic pressure overload [89]. Here, TRPC6 is linked to renal fibrosis.