We previously noted that TRPC6 is not the only TRPC channel expressed in glomeruli, and it has been reported that a combined global knockout of TRPC3, TRPC6, and TRPC7 in mice reduced albuminuria and histological kidney damage in the streptozotocin (STZ) model of type 1 diabetes in mice up to at least 12 weeks of age [83], but it is not known if the protection by these multiple knockouts would have been more sustained, and it is not known if this strain of mice becomes insulin-resistant. The gene discussed is TRPC6; the disease is type 1 diabetes mellitus.