This study focussed on a subset of enriched clusters, namely the effect of TGF-β1 on exfoliation material, extracellular matrix remodelling, extracellular signal molecules, oxidative stress and modulation of the antioxidant system, the unfolded protein response and retinoic acid signalling because of their relevance to the pathogenesis of XFG. Here, TGFB1 is linked to exfoliation syndrome.