TGFB1 and exfoliation syndrome: Interestingly, direct liberation of TGF-β from the LAP-TGFβ complex by reactive oxygen species has only been demonstrated for TGF-β1 and not for the other two TGF-β isoforms [78]; so perhaps this particular mechanism plays a larger role in the pathogenesis of XFG in which TGF-β1 is the predominant TGF-β isoform.