We have previously reported [10] a novel in-frame SRF::E2F1 fusion in two cases of myoepithelial neoplasms (MN) of the soft tissue: a mixed-type tumor harboring FUS::KLF17-rearrangement (case L108) and a spindle cell myoepithelioma with no evidence of other gene fusions (case L107), both lacking pathological evidence of malignancy. Here, E2F1 is linked to myoepithelial tumor.